| Derriford Hospital | University hospital | Derriford Rd | Daily Open 24 hours |
| Derriford Hospital -Ear, Nose & Throat | Otolaryngology clinic | Derriford Hospital, 06 Derriford Rd | Daily Open 24 hours |
| Devon and Cornwall Motorhome and Caravan Service Repair Centre | Caravan repair shop | Unit K&M, Boringdon Mill Business Park, Lister Cl, Galileo Cl | Mon–Fri 08:30–16:30 |
| Devon Cleaning South Hams | Cleaning service | Unit 36, City Business Park, Somerset Pl | Mon–Fri 09:00–17:00 |
| Devon K9 Clinic by Sayenchi | Fertility clinic | Unnamed Road | Daily 10:00–22:00 |
| DevonDents | Vehicle dent removal service | 4 Slade Cl | Mon–Sat 09:00–16:00 |
| Devonport High School for Girls | Single sex secondary school | Lyndhurst Rd | Mon–Fri 08:50–15:35 |
| Devonport Park | Park and garden | 9RGG+9M | Daily Open 24 hours |
| Devonshire House & Lodge Care Home | Nursing home | Woolwell Rd | Daily Open 24 hours |
| Diamond Disposables | Catering supplier | 1 Breakwater Rd | Mon–Thu 09:00–17:00 |
| Diamond Drilling Services SW Ltd | Drilling contractor | 58 Pegasus Pl | Daily Open 24 hours |
| DL Painting & Decorating - Plymouth - Plympton - Plymstock - Ivybridge | Painter and decorator | 42 Yealmpstone Dr | Daily Open 24 hours |
| Dorcas Media Limited | Public relations firm | Dorcas Media Cornwall, 48 Fore St, Saltash PL12 6JL Dorcas Media Devon, 4 Esplanade House | Mon–Sat 09:00–18:00 |
| Drainage Plymouth Blocked Drains | Drainage service | 31 Palmerston St | Daily Open 24 hours |
| Drake Mill Business Park | Business park | Estover Rd | Daily 08:30–17:30 |
| Dream Bathrooms Ltd | Bathroom renovator | Mill Business Park, Unit 14-15, Sugar, Billacombe Rd | Thu 09:00–17:00 |
| Dyson Dave, Plymouth | Vacuum cleaner repair shop | 1 Kent Rd | Mon–Sat 09:00–17:00 |
| EarthCoat | Artist | 5 Merafield Cl | Mon–Sat 08:00–17:00 |
| Eldreds | Auction house | Devon Enterprise Facility, 1 Belliver Way | Mon–Fri 08:30–17:00 |
| elesse hair and beauty salon | Hairdresser | Jubilee Buildings, Peverell Park Rd | Tue 09:00–20:00 |
| Elmes carpentry & construction ltd | Carpenter | 12 Litchfield Cl | Mon 07:00–17:00 |
| Embankment Road Post Office | Post office | Embankment Rd | Tue 09:00–17:30 |
| Entry Group UK - Plymouth Depot | Door supplier | Unit 12c, Galileo Cl | Sat Open 24 hours |
| Envy Hair Design | Hairdresser | Shopping Centre, Unit 9 The Broadway | Mon 09:00–14:00 |
| Epic Workwear | Print & Embroidery | Printing shop | 14 The Dell | Mon 09:00–17:00 |
| Equanimity Clinical Psychology Services | Psychologist | Ground floor, Office 9, Genesis building, 235 Union St | Mon–Thu 09:00–17:00 |
| EQUILIBRIUM-Personal Training & Sports Massage | Personal trainer | UNIT 26, Devonshire Meadows, Broadley Park Rd | Daily 06:00–22:00 |
| Ercle Architects | Architect | 76 Hyde Park Rd | Mon–Fri 09:00–17:00 |
| Every Corner Distribution Ltd | Distribution service | 10 Thornbury Rd | Mon–Fri 09:00–16:00 |
| Excel Plymouth Ltd | Custom t-shirt shop | The Warehouse, 12b Commercial St | Mon 09:00–17:00 |