| Smokemart | Lottery retailer | 45 London Rd | Mon–Sat 06:00–03:00 |
| Smokers paradise | Smoke shop | 26 Sydney St | Mon–Sat 10:00–18:00 |
| Snobby Doggy | Dog trainer | 6 Lambourne Cl | Mon–Fri 09:00–17:00 |
| Snoopers Paradise | Antique shop | 7/8 Kensington Gardens | Mon–Sat 10:15–17:45 |
| Snuffle Shuttle - Dog Walker, Brighton | Dog walker | Wiston Rd | Mon–Fri 10:00–19:00 |
| Social Firefly | Marketing agency | Freedom Works - Barts House, Black Lion St | Mon–Fri 08:00–17:00 |
| Somatic Frequency | Kinesiologist | Mackie Ave | Mon 10:00–14:30 |
| Sonia Sarkali Psychic Tarot | Clairvoyant | 3 Rushlake Rd | Mon 11:00–20:00 |
| Soundfangled | Audio visual equipment hire service | 66 Hartington Rd | Mon–Fri 09:00–17:30 |
| South East Dance at The Dance Space | Events venue | The Dance Space, 2 Market Sq, Circus St | Mon–Sat 08:00–21:00 |
| Southeast Motors Jaguar Brighton | Jaguar dealer | Crowhurst Rd | Mon 08:00–18:00 |
| Southern Cross Evangelical Church | Evangelical church | 103 Trafalgar Rd | Tue 18:30–19:30 |
| Spark & Bell | Lighting shop | Ground Floor, victoria house, Vale Rd | Mon–Fri 09:00–16:30 |
| Specs Opticians Brighton | Sunglasses shop | Opposite Bert’s Homestore, 22 Kensington Gardens | Thu 10:00–18:00 |
| Speech & Language Therapist Brighton | Speech pathologist | 16 Surrenden Cres | Mon–Fri 09:00–18:30 |
| Spicy Wife-Portslade | Indian takeaway | 38 Trafalgar Rd | Mon–Tue 16:30–22:30 |
| St Georges Clinic | Tattoo-removal service | 10b Matlock Rd | Thu 08:00–17:30 |
| St Joseph's - East Brighton Catholic Parish | Catholic church | 6 Wellington Rd | Mon–Fri 18:00–19:00 |
| St. John the Baptist Catholic School, Brighton | Catholic school | Whitehawk Hill Rd | Mon 07:30–17:30 |
| StarVita | Beautician | 16 Church St | Mon–Sat 10:00–19:30 |
| Steve Baker - Producer, Mix Engineer, Musician | Music producer | 1 Bonchurch Rd | Thu–Fri 10:00–22:00 |
| Stick It On | DJ | 13-17 Marlborough Pl | Mon 09:00–18:00 |
| Stickland Wright Architecture and Interior Design | Interior designer | 23 Vine St | Mon 08:30–17:30 |
| Strafford Cars of Brighton | Car dealer | 74 Preston Rd | Mon–Sat 09:00–17:00 |
| Strafford self drive | Van rental agency | 74 Preston Rd | Mon–Fri 08:30–17:30 |
| Studio Tamanè | Knitting instructor | Bmecp Centre, 10 Fleet St | Daily 10:00–16:00 |
| Style me pretty | Hair extension technician | 33 Clifton Hill | Wed 10:00–18:00 |
| Sun Harvest | Fruit and vegetable wholesaler | Unit 8.1, The Hyde Business Park | Mon–Fri 02:00–15:00 |
| Supaphoto | Video duplication service | 113 Valley Dr | Mon–Sat 08:30–18:00 |
| Superior Dental Ceramics | Dental laboratory | 2 Grantham Rd | Mon–Fri 08:00–17:00 |