| Emma Morgan Wholesale | Clothing wholesaler | 39 Broughton St | Mon–Fri 09:00–18:00 |
| Empire Exchange | Collectibles shop | 1 Newton St | Daily 10:00–18:00 |
| Empire Executive Travel Ltd | Chauffeur service | First Floor, Swan Buildings, 20 Swan St | Daily Open 24 hours |
| Ena Mill Retail | Department store | Flapper Fold Ln | Mon–Fri 10:00–17:00 |
| ENT Manchester | Mr Rohit Kumar | Private hospital | 170 Barlow Moor Rd | Daily 08:00–20:00 |
| Epicerie Ludo / Ludo's | Deli | 46 Beech Rd | Mon–Wed 08:00–20:00 |
| Escape The Van | Escape room centre | 96 Mauldeth Rd W | Daily 09:54–05:55 |
| Estate Agents Didsbury, Letting Agents Didsbury - Open House | Real estate | 21 Old Oak St | Daily Open 24 hours |
| Ever Prime Painting and Decorating | Painter and decorator | 12 Brook Rd | Daily Open 24 hours |
| Evuna Deansgate | Spanish restaurant | 277-279 Deansgate | Mon–Sat 12:00–23:00 |
| Excel Drainage | Septic tank service | Pioneer Mill, 46 Milltown St | Daily Open 24 hours |
| Expo Lounge | Family restaurant | 766 Wilmslow Rd | Mon–Thu 09:00–22:00 |
| F45 Training Manchester NQ | Fitness centre | 77 Piccadilly | Mon–Fri 06:00–20:00 |
| Fairfield Arms | Gastropub | 92 Manchester Rd, Greater | Mon–Thu 11:00–23:00 |
| Falafel | Falafel restaurant | 26 Wilmslow Rd | Daily 10:00–00:00 |
| Falcon Relocation Group Ltd, Man and Van & Removals Services | Waste-management service | 9 Hexham Rd | Mon–Fri 08:00–20:00 |
| Fallowfield Bowling & Lawn Tennis Club | Lawn bowls club | 81 Wellington Rd | Mon–Fri 08:00–00:00 |
| Farewells Pet Crematorium | Pet funeral service | Crofters House, Moss Brook Rd | Mon–Sat 08:30–17:00 |
| Fast Trak Digital | Antenna service | 85 Station Rd | Mon–Fri 08:00–21:00 |
| Fire Protection Services NW Ltd | Fire protection service | Unit 3, 5 Roger St | Daily Open 24 hours |
| Firwood Carpets & Flooring Denton | Flooring shop | 27 Ashton Rd | Mon–Fri 09:00–17:00 |
| Fisher Clearance Services | Junk removal service | The Power Station, Trafford Park Rd | Daily 07:00–22:00 |
| Fitzgeralds Builders & Roofing Contractors Ltd | Custom home builder | 1 Chapel Rd | Daily 08:00–20:00 |
| Fix Computers | Screen repair service | 46 Barry Rd | Mon–Fri 08:30–19:30 |
| Fletchs Customs | Vehicle wrapping service | Praed Rd | Daily Open 24 hours |
| Flixton Golf Club | Golf club | 269 Church Rd | Mon–Fri 09:00–16:00 |
| FLUX Designs | T-shirt shop | Unit 6, FLUX Designs, 20-22 Mary St | Mon–Fri 10:00–16:00 |
| Focus with Faigy | Life coach | Bartle House Oxford Court | Mon–Thu 09:00–17:00 |
| Food Research Lab | Food and beverage consultant | MIIC Unit 52-56, Greenheys Business Centre, Pencroft Way | Mon–Thu 09:00–19:00 |
| Forsyth Music Shop | Musical instrument shop | 126 Deansgate | Mon–Sat 10:00–17:30 |