| Chester Road Household Waste and Recycling Centre - R4GM/SUEZ | Household waste recycling centre | Chester Rd | Sat–Sun 08:00–20:00 |
| Chinese Education Cultural Community Center | Education centre | St Bede's College Regis building, Wellington Rd | Sun 11:30–14:30 |
| Chocolate Fountain Hire Manchester - KMH DISPLAYS | Party equipment rental service | Manchester M1 1AF | Daily Open 24 hours |
| Chokdee Thai Massage and Spa Manchester | Erotic massage | 6 Park Pl | Daily 10:00–22:00 |
| Chorlton Evangelical Church | Evangelical church | Chorlton Grn | Wed 19:45–21:00 |
| Christ Temple International Church | Evangelical church | 101 Osborne St, Greater | Daily 04:11–18:59 |
| City Centre Cruises | Boat hire service | 92 Castle St | Daily 10:00–17:00 |
| City of Manchester Institute of Gymnastics | Gymnastics academy | Garratt Way | Mon–Thu 12:30–21:00 |
| Clampdown Records | Record shop | 9-11 Paton St | Mon–Fri 10:30–17:30 |
| Clarkes Bespoke Design Ltd | Architectural designer | 83 Ducie St | Daily Open 24 hours |
| Clarks Hill Kennels & Cattery | Cattery | Off Ringley Rd | Daily 09:00–16:00 |
| CleanCuts Property Services LTD | Lawn care service | Claremont Rd | Mon–Sat 09:00–21:00 |
| Cloud Aerial Arts | Dance school | Unit A, Aldow Enterprise Park, Blackett St | Mon–Tue 12:00–21:00 |
| Cloudwater Brew Co Taproom | Microbrewery | Piccadilly Trading Estate, Unit 9, Gidding Rd | Mon–Thu 14:00–22:00 |
| Coco Mart | Indian grocery shop | Mill Green St | Daily 09:00–23:00 |
| Colin Khalid Electrical Ltd | Electrical products wholesaler | 53 Knowsley St | Mon–Fri 09:30–17:30 |
| Company Shop Middleton | Shop | Stakehill Industrial Estate, Touchet Hall Rd | Mon–Fri 08:00–20:00 |
| Compliant Retrofits UK | Insulation contractor | Unit 26, Longsight Business Park, 69 Hamilton Rd | Daily Open 24 hours |
| Continental | Pizza takeaway | 127 Burton Rd | Mon–Thu 16:00–00:00 |
| Cotton Field Park | City park | 6LN, Cotton St | Daily 08:00–19:00 |
| Crimson Rose Tattoo and Piercing | Tattoo and piercing shop | 1028a Stockport Rd | Mon–Fri 11:00–17:30 |
| CUPRA City Garage Manchester | Cupra dealer | 4-6 St Ann St | Mon–Fri 08:30–17:30 |
| Dace Specialist Car Centre Manchester | Used car dealer | 718 Liverpool Rd | Mon–Fri 09:00–19:00 |
| Daisy Nook Country Park | Country park | Stannybrook Rd | Mon–Fri 09:00–16:00 |
| Datum Datacentres (MCR1, Manchester) | Data center | Delta House, MCR1, Wavell Rd | Daily Open 24 hours |
| David Villegas Farrier Service | Horseshoe smith | 6 Hartley Ave | Mon–Thu Open 24 hours |
| Dawateislami Islamic and Education Centre | Mosque | 979-981 Rochdale Rd, Greater | Mon–Fri 10:00–18:00 |
| Debt Support Direct | Credit counselling service | Bank Chambers, 93 Lapwing Ln | Mon–Fri 09:00–20:00 |
| Decibel sound solutions - Manchester Sound Hire | Audio visual equipment hire service | 19 Kings Cres | Daily Open 24 hours |
| Deepakology | Psychiatrist | 48 Gorse St | Daily Open 24 hours |