| Deeper Life Bible Church, Manchester | Religious organisation | Lillian grove, Reddish Stockport, Greater | Tue 19:00–21:00 |
| delightfuldisplaysmcr | Charcuterie | Oldham Rd | Mon Open 24 hours |
| Depot Climbing Shop | Rock climbing | Unit A5/A6, Southmoor Industrial Estate | Mon–Fri 09:00–22:00 |
| Desi Kiranam | Supermercado indio | 666 Bolton Rd | Mon–Sat 09:00–21:00 |
| dictate2us Limited | Transcription service | 8 Haymarket St | Sat–Sun Open 24 hours |
| Didsbury Sports Ground | Function room facility | Didsbury Sports Ground, Ford Ln | Sun 09:00–21:00 |
| Diecast | Beer hall | 51 Ducie St | Wed 16:00–23:00 |
| DIOR Manchester Selfridges | Leather goods shop | Ground floor & 1st floor, 1 Exchange Sq | Mon–Tue 10:00–20:00 |
| dishsat | Cable provider | 327 Oldham Rd | Daily Open 24 hours |
| DOA foods ( Afro-Caribbean) | African goods shop | Unit 3, Lime Square, Ashton Old Rd | Mon–Sat 08:00–20:00 |
| DockyDock | Marina | 146-182 Bradford Rd | Daily Open 24 hours |
| Don Tacos | Mexican restaurant | 61-63 Wilmslow Rd | Daily 12:00–23:00 |
| Doodle Pots (Paint a Pot & crafts) | Painting studio | 2 Lees Rd Mossley Ashton-under-lyne, Greater | Wed–Thu 10:00–16:00 |
| DosaXpress | South Indian restaurant | 19 Copson St | Daily 12:00–22:30 |
| Dransfield Engineering Services Ltd | Precision engineer | Unit 5, Astra Business Park Guiness Road, Trafford Park | Daily Open 24 hours |
| Draycott Browne Solicitors | Criminal defence lawyer | 12 Oxford Ct | Daily Open 24 hours |
| Dreamers' Learning | School | 113 Abbey Hey Ln | Daily 08:00–22:00 |
| DreamLife Wedding | Wedding photographer | 17 Meadow Way | Daily Open 24 hours |
| Drew Wilby Photographics | Photographer | 17 Kingswood Rd | Daily Open 24 hours |
| Drinkwater Park | Park and garden | Prestwich, Manchester M45 7JZ | Daily Open 24 hours |
| Ducie Street Warehouse | Lounge bar | Ducie St | Mon 07:30–19:00 |
| Dukes 92 | Bar & grill | 18 - 25 Castle St | Mon–Thu 11:30–23:00 |
| Duo Wellness Center | Massage spa | 1272 Ashton Old Rd | Daily 10:00–20:00 |
| East Street Trafford Centre | Singaporean restaurant | The Orient, Trafford Blvd | Mon–Tue 11:00–21:30 |
| Eastern Pearl | Banquet hall | 250 Plymouth Grove | Daily 09:00–23:00 |
| Ebenezer Baptist Church | Baptist church | Linwood St | Tue 10:00–12:00 |
| Edit Suits Co. Manchester | Tailor | 54 King St | Mon–Fri 10:00–19:00 |
| EES Vertical Transportation Engineering Support Ltd | Lift service | Park, Unit 1 Townley St, Hanson St | Sun 08:00–16:30 |
| Electriko Electrical Services Manchester | Solar energy company | First Floor, 20 Swan St | Daily Open 24 hours |
| Ellesmere Golf Club | Golf course | Old Clough Ln | Daily 08:00–18:00 |