| DCY Europe | Import export company | Ind Park, The Showroom, Alan Farnaby Way | Mon–Fri 09:30–17:00 |
| Denby Outlet | Pottery shop | Unit 103, York Designer Outlet Village, St Nicholas Ave | Mon–Sat 09:30–20:00 |
| Derrings Boarding Kennels | Pet boarding service | New Derrings Farm, Hag Ln | Mon–Fri 08:30–10:30, 16:00–17:45 |
| Descubre York, Tours en Español - Português | Sightseeing tour agency | 2 Chancery Rise | Daily 05:00–00:00 |
| Designer Outlet York | Shopping outlet | St Nicholas Ave | Mon–Fri 09:30–20:00 |
| Developing Business Excellence Limited® | Business development service | Brabourne House, 2 Trinity Cl | Mon Open 24 hours |
| DJB Photography | Commercial photographer | The Old Post Office | Tue–Fri 08:30–18:00 |
| DMK Services | Arborist service | Holtby Ln | Daily Open 24 hours |
| DNB Home & Stone | Fireplace manufacturer | 5, Marston Moor Business Park | Mon–Fri 07:30–15:30 |
| Double Dutch Pancake House | Pancake restaurant | 7 Church St | Mon–Fri 09:00–15:00 |
| Dough Eyed | Pizza restaurant | 7 Jubbergate | Mon–Thu 11:30–22:00 |
| Dove Furniture & Kitchens | Joiner | Unit 1, York Road Nurseries, York Road | Mon–Fri 08:30–16:30 |
| Drive Hyundai York | Hyundai dealer | Drive Hyundai, Great N Way | Mon–Fri 08:30–18:00 |
| Dryfix Preservation Ltd | Water damage restoration service | Unit 4, Dryfix Preservation Ltd, Isis Court, Rosetta Way | Mon–Fri 09:00–17:00 |
| Eamonn Byrne Landscape Architects Ltd (EBLA) | Landscape architect | 5-6 King's Sq | Mon–Fri 09:00–17:00 |
| Easingwold DIY | DIY store | Tylers Walk, 2, Crabmill Ln | Mon–Tue 09:00–16:00 |
| Easingwold Market | Market | Market Pl | Fri 08:00–15:00 |
| Easy Rent Appliances | Appliance rental service | Mill Garth, Crayke Rd | Mon–Fri 08:00–18:30 |
| Ebor Windows | Window supplier | Unit 1 Keswick Way | Mon–Fri 09:00–16:00 |
| EborAcumen | Tax advisor | 136 Boroughbridge Rd | Mon–Fri 08:30–17:00 |
| ECS Engineering LTD | Engineer | Unit 2c York Road Nurseries | Mon–Wed 08:00–17:30 |
| Edge Stickers | Decal supplier | Shires Bridge, The Old Mill Building, York Rd | Mon–Fri 09:00–17:00 |
| Edmund Optics | Optical products manufacturer | 1 Opus Ave | Mon–Fri 08:00–17:00 |
| EGL Autos | Car bodywork mechanic | Unit 1a Keswick Way | Mon–Fri 08:00–17:30 |
| Eliments | Window installation service | Bell Farm, A19 Riccall Road, Escrick | Mon 09:00–17:00 |
| Elise Designs - Beautiful, handmade wedding dresses | Dressmaker | Westfield Ct | Mon–Tue 10:00–18:00 |
| Elite Brick & stone Contractors | Masonry contractor | 74 St Benedict Rd | Thu–Fri 08:00–19:00 |
| Elliott Building Contractors | Home builder | 359 Thanet Rd | Thu 07:00–20:00 |
| En Pointe | Ballet school | Unit 2, Rose Ave | Mon 09:00–20:00 |
| Energise Leisure Centre | Leisure centre | Cornlands Rd | Mon–Fri 06:30–21:30 |