| Disability Partnership | Disability services and support organization | Centre for, Centre for Independant Living, Beaufort St | Mon–Thu 09:00–17:00 |
| Dog & Partridge | Pub | Manchester Rd | Daily 12:00–23:00 |
| Domlets - Estate & Letting Agents in Warrington | Apartment letting agency | 177 Orford Ln | Mon–Fri 09:00–16:00 |
| Dorado Lounge | Breakfast restaurant | 19 Market Place | Mon–Thu 09:00–22:00 |
| Dr Schär UK Ltd | Food manufacturer | 401 Faraday Street, Birchwood Park Faraday St | Mon–Fri 10:00–16:00 |
| Drain Unblocking Warrington | Drainage service | 1st Floor, Rutherford House, Warrington Rd | Daily Open 24 hours |
| Drill Direct Ltd | Drilling contractor | Greys Court, 19, Kingsland Grange | Mon–Fri 06:00–17:30 |
| Drink Dash Ltd | Beer shop | Unit G1B6, Norman St | Tue–Thu 21:00–04:59 |
| DSW Capital plc (Dow Schofield Watts) | Financial advisor | 7400 Daresbury Pk | Mon–Fri 09:00–17:30 |
| DT Electrical - Electrician in Warrington | Electrician | 18 Coleport Cl | Daily 09:00–17:00 |
| Dunkys Day Nursery | Nursery school | 101 Barrow Hall Ln | Mon 07:30–18:00 |
| Dynamic Grounds Maintenance Ltd | Contractor | Tanners Farm, 78 Twiss Green Ln | Mon Open 24 hours |
| Earful - Ear Wax Removal & Hearing Tests | Hearing aid shop | Earful, 4 Rylands St | Mon–Wed 09:00–18:00 |
| East Orient | Buffet restaurant | 54 Horsemarket St | Mon 12:00–15:00, 17:00–21:00 |
| Eddie Stobart | Trucking company | Stretton Green Distribution Park, Langford Way | Mon Open 24 hours |
| Efinity Finance | Finance broker | 5 Manchester Rd | Mon 09:00–17:00 |
| EJ Osteopathy | Osteopath | 46 Kinross Cl | Fri 09:30–18:00 |
| Eliza Henri - The World of Blanks | Craft shop | Unit 4C, penketh business park | Sat 09:00–18:00 |
| Ene Holistics | Sports massage therapist | 279a Thelwall Ln | Thu–Fri 10:00–20:00 |
| Energy Ombudsman | Consumer advice centre | Daresbury Park, 3300 | Mon–Fri 08:00–18:00 |
| Entec Doors Services ltd | Door supplier | Aston Court, Unit 17 & 18, Kingsland Grange | Daily Open 24 hours |
| Epics 'N' Stuffs | Hobby shop | Unit A, The Stables, Buckley St | Fri 10:00–22:00 |
| Essens Uk Ltd | Cosmetics wholesaler | Unit 13, Albion Park | Mon–Fri 07:30–16:00 |
| Eternity Bridal Wear Ltd | Bridal shop | 11 Palmyra Square S | Tue–Fri 10:00–15:00 |
| Executive Medical Services Limited | Life insurance agency | 24 Manchester Rd | Mon–Fri 09:00–17:00 |
| F&F Clothing | Baby shop | Winwick Rd | Mon–Sat 06:00–00:00 |
| Fairway Rider G3 | Golf cart dealer | Unit 20 Ravenhurst Ct | Tue 08:00–15:30 |
| FAME Creative Talent | Performing arts group | 28 - 32 Milner St | Mon–Thu 16:00–21:00 |
| Family law solicitors Warrington | Children Solicitors Warrington | Divorce Solicitors Warrington | Family lawyer | My Mackenzie, Regus Cinnamon Park Crab Lane Cinnamon | Mon–Fri 09:30–17:00 |
| FASTCRETE Warrington Grab Hire And Ready-Mix Concrete Suppliers/Aggregate suppliers recycled-quarried. | Ready-mix concrete supplier | New Cut Lane | Thu–Fri 08:00–18:30 |