| Craft Making Ideas | Gift shop | 20 Woodbridge Cl | Mon–Fri 09:30–17:00 |
| craftsuprint ltd | Arts and crafts shop | Unit 27, Burtonwood Industrial Centre | Daily 09:00–17:00 |
| Croft Golf Centre | Golf driving range | Cross Ln | Sun 10:30–17:00 |
| Croft Heating Ltd | Central heating service | 50 Browmere Dr | Mon–Fri 08:00–18:00 |
| Croft riding centre | Horse-riding service | Spring Ln | Mon 09:00–21:00 |
| Croft Village Memorial Hall | Village hall | 5 Mustard Ln | Mon–Thu 08:00–22:00 |
| Crompton Opticians | Optician | 6 Common Ln | Mon–Fri 09:00–17:30 |
| Crown Flooring Ltd | Flooring contractor | Easter Ct, Europa Blvd | Mon–Fri 09:00–17:00 |
| CTA Systems I.T. Solutions Ltd | IT support and services | Cherryvale Lodge, 6 Boverton Cl | Thu–Fri 09:00–18:00 |
| Culcheth Charcoal Grill | Kebab shop | 18 Church Ln | Mon–Tue 16:00–23:00 |
| Culcheth Christian Fellowship | Church | 85 Hob Hey Ln | Thu 19:00–20:30 |
| Culcheth Healing | Reiki therapist | 55 Severn Rd | Mon–Fri 08:00–19:00 |
| Culcheth Linear Park | Park and garden | 88 Wigshaw Ln | Daily Open 24 hours |
| Culcheth Medical Centre | Medical centre | Jackson Avenue, Jackson Ave | Mon–Thu 08:00–18:30 |
| Culcheth Natural Therapy | Acupuncturist | 25B Common Ln | Mon–Tue 09:00–21:00 |
| Cumbria Heating Components | Heating equipment supplier | Unit 1B, Newcut Lane Ind Est ,Newcut Lane ,Woolston, 2c New Cut Ln | Mon–Fri 08:00–17:00 |
| D4 Medicals (HGV Medicals, Taxi Medicals, Crane Operator Medicals, Insurance Medicals) | Medical certificate service | D4 Medicals, Wilderspool Business Park, Whitehouse, Gainsborough Rd | Mon–Sat 09:00–17:00 |
| DANA Brevini Power Transmissions | Transmission shop | Kestrel Court, Centre Park | Mon–Fri 09:00–19:00 |
| Danny’s barbers | Barber shop | 446 Warrington Rd | Mon–Sat 08:30–18:00 |
| Dante Group | Air conditioning system supplier | 212 Europa Blvd | Daily Open 24 hours |
| Daresbury Laboratory | Laboratory | Keckwick Ln | Daily 08:00–19:00 |
| Dark Side Of The Spoon | Dessert restaurant | 2 Time Square, Market, Unit 35 Academy Way | Mon–Thu 09:00–17:00 |
| Darryl C Price | Water damage restoration service | 98 Delery Dr | Daily Open 24 hours |
| Dave Pluck | Off track betting shop | Fearnhead cross, Insall Rd | Mon–Fri 09:30–21:30 |
| DH Fencing Supplies | Fence contractor | The Depot, Statham Ave | Mon–Fri 08:30–17:00 |
| Digi-Me-Bobs | Computer service | 452 Warrington Rd | Mon 09:00–17:00 |
| Dimension Imprinted Concrete Driveways | Concrete contractor | 247 Warrington Rd | Mon–Fri 08:00–17:00 |
| Dine Contract Catering | Catering food and drink supplier | EngineRooms, Birchwood Park Ave | Mon–Fri 09:00–17:00 |
| Dinex Exhausts Ltd | Exhaust silencer shop | Unit7, Westway21, Chesford Grange | Mon–Fri 09:00–17:00 |
| Direct Garden Structures | Garden building supplier | Farm Alder Root Ln | Daily 09:00–17:00 |