| Easy Domains | Internet marketing service | 7 St Georges Park | Mon–Fri 09:00–16:30 |
| Easy Oil | Heating oil supplier | Easy Oil, The Fuel Depot, Crossley House Ind Est, Leyland Rd | Daily Open 24 hours |
| Eckersley | Commercial property estate agent | 25a Winckley Square | Mon–Thu 09:00–17:30 |
| Eco Home Insulation | Insulation contractor | 2B, Riversway | Mon–Fri 08:00–17:00 |
| Eco Renewables Group Limited | Solar energy company | 308a Station Rd | Fri 09:00–13:00 |
| Ecotest Limited | Mechanical engineering | Unit 10, Bradley Hill Farm | Mon–Fri 09:00–17:00 |
| EGM - Elswick Garden Machinery | Lawn mower shop | The Croft | Mon–Fri 08:00–17:00 |
| EJM Investigations | Private investigator | Cotton Ct, Church St | Daily Open 24 hours |
| Elan Beauty Company | Beautician | 24 Dowbridge | Tue–Wed 10:00–18:30 |
| Elctric Ltd | Electrician | 23 Whittingham Ln | Daily Open 24 hours |
| Elliot Grounds Maintenance | Lawn care service | 2 Greenbank Ave | Daily 09:00–20:00 |
| Elroi Multi cuisine kitchen | English restaurant | 182A Plungington Rd | Mon–Fri 12:00–21:00 |
| Elswick Cattery | Cattery | Bonds Ln | Daily 08:30–10:00, 16:00–17:30 |
| Elvin's Kirkham | Lebanese restaurant | 83 Poulton St | Mon–Sat 11:30–21:00 |
| Envirosafe Chartered Consultants | Occupational safety and health | Unit 5, Albert Edward House, The Pavilions | Daily Open 24 hours |
| EPS Northwest Ltd | Solar energy system service | EPS Northwest Ltd, St Thomas way | Fri 08:00–17:30 |
| Equine Herbology | Vitamin & supplements shop | The Weind | Sun 08:30–17:00 |
| Eru Ltd - Ledbrite | Lighting shop | 12 Plungington Rd | Mon–Thu 08:00–17:30 |
| Essentialise Workplace Wellbeing | Occupational health service | Suite 4, 9-15 Ribbleton Ln | Mon 08:00–20:00 |
| Exo Prosthetics | Orthotics & prosthetics service | 1 Cameron Ave | Mon–Thu 08:00–16:00 |
| Family law Lawyer Manchester - Divorce solicitors Preston | Family lawyer | Biz Space, Preston Technology Centre, Marsh Ln | Mon–Sat 09:00–17:00 |
| Fantasy Prints | 3D printing service | 12 Black Bull Ln | Mon–Sat 09:00–18:00 |
| Farmplus Construction Ltd | Timber merchant | Shay Lane Industrial Estate, Shay Ln | Mon–Fri 08:00–17:00 |
| FastLine Coatings Ltd | Powder coating service | Wellfield Business Park, Unit 9 Wellfield Rd | Mon 08:00–16:00 |
| Fenwick Alloys (Mobile Alloy Refurbishment) | Wheel alignment service | 4 Ash Ln | Mon–Fri 08:30–17:30 |
| Fertility Acupuncture and IVF Support | Acupuncturist | 129 Lytham Rd | Mon–Fri 10:30–15:00 |
| Fired 4 U | Pottery classes | 15-17 Hennel Ln | Wed–Fri 10:00–17:30 |
| Fireworks Shop | Tienda de artículos pirotécnicos | 225 Station Rd | Mon–Sat 10:00–16:00 |
| first call locksmiths | Locksmith | 5 | Daily Open 24 hours |
| Fish Insurance | Insurance company | Longridge Rd | Thu 09:00–17:00 |