| CGS Glazing Ltd | Double glazing installer | Mounsey Rd | Mon 07:00–16:00 |
| Chemical Guys Hub | Servicio de limpieza de automóviles | 50-51 Dollywaggon Way | Fri 10:00–18:00 |
| CHR Food Service Equipment Ltd | Catering supplier | Astar House, Fourfields | Mon–Fri 09:00–17:00 |
| Christ Central Preston | Christian church | St Pius Preparatory School, Garstang Rd | Sun 10:00–13:00 |
| Chun Cha | Asian fusion restaurant | 8, Victoria and Albert Buildings | Mon–Tue 09:00–19:00 |
| City Eats | Food products supplier | 236 St Paul's Rd | Mon Open 24 hours |
| City Investment & Insurance Services Ltd | Financial advisor | 251 Tulketh Brow | Thu 09:30–17:30 |
| City of Preston Gymnastics Club | Gymnastics club | Unit 2 Campbell St | Mon 16:00–21:00 |
| CLA Fuels | Fuel supplier | CLA Fuels, The Fuel Depot, Crossley House Ind Est, Leyland Rd | Daily Open 24 hours |
| Clear View Window Cleaning | Pressure washing service | Studholme Ave | Mon–Fri 09:00–18:00 |
| Cliff House Nursery Ltd | Nursery | 19 Lambert Rd | Mon–Fri 08:00–18:00 |
| Cojoe Ltd - Animation | Animation studio | 24 Poulton St | Daily Open 24 hours |
| Compass Fuel Oils | Fuel supplier | The Fuel Depot, Crossley House Industrial Estate, Leyland Rd | Thu Open 24 hours |
| Complete Convey | Legal services | 2, Roundhouse Court, South Rings Business Park | Mon–Fri 09:00–17:00 |
| Compound Paraplanning | Business administration service | Old Docks House, 90 Water Ln | Mon–Thu 09:00–17:00 |
| Concept Claim Solutions | Water damage restoration service | 3, Fairways Business Park | Thu 09:00–17:30 |
| Concept Cleaning Services & Facilities Management Ltd | Cleaning service | 2 Squirrels Chase | Mon–Wed 07:30–20:00 |
| Concept Construction Ribble Valley | Flooring contractor | 10 Higher Rd | Mon–Fri 09:00–17:00 |
| Contact Packaging | Packaging company | 12, Old Mill Industrial Estate | Thu 09:00–17:00 |
| Core 3 Wellness: Injury Rehabilitation & Movement Clinic | Physical therapy clinic | 14 Watkin Ln | Mon 08:00–18:00 |
| Corner Garage Volvo Specialist | Car dealer | Lytham Rd | Mon–Fri 08:00–17:30 |
| Corona Contracts Ltd | Blinds shop | 4a, Hillthorpe Farm, Unit 4f Knoll Ln | Mon–Fri 08:00–17:00 |
| Coronet Hire Service Wedding & Event Hire Specialists | Party equipment rental service | Parles Farm, Bank Ln | Mon–Fri 09:30–16:30 |
| Costume House Hire | Dance shop | 7 Crofts Cl | Mon–Fri 09:00–17:00 |
| Country Farm Stud Ltd | Equestrian centre | Lancaster Rd | Daily 09:00–17:00 |
| County Car and Van Rental | Car rental company | 322 Aqueduct St | Mon–Fri 08:30–17:30 |
| CPC Farnell | Electronic parts supplier | Component House, Faraday Dr | Mon 07:00–17:00 |
| Crafty Diane Pottery Painting , Gift and Art Gallery, Craft Workshops | Arts and crafts shop | Unit 4, Bridgehouse Marina, Nateby Crossing Ln | Wed–Thu 11:00–16:00 |
| Cre8 Chartered Surveyors & Building Consultancy | Surveyor | 9-10 Cross St | Mon–Fri 08:30–17:00 |
| Creation Honey | Honey farm | 5 Elms Dr | Mon 09:00–21:00 |