| Creative UPVC | Aluminium supplier | 15 Kingsbarn Cl | Mon–Fri 09:00–17:00 |
| Crystal Clear Details | Valeting service | Unit 1, West view farm | Daily 08:00–18:00 |
| Crystal Leisure Swimming Pools | Swimming pool contractor | B4, Anchorage Business Park, Riversway Docklands | Mon 08:00–17:00 |
| Cuerden Valley Park | Park and garden | Berkeley Dr | Daily Open 24 hours |
| Curiosity Corner Play | Indoor playground | 194 Hesketh Ln | Sat 09:15–17:30 |
| CustomsLink® | Customs Broker for Hauliers, Importers & Exporters | Customs broker | 12 Sceptre Ct | Sat 08:00–16:00 |
| D B Joinery & Building Contractors Ltd | Building firm | 44 Aldwych Dr | Thu 08:00–17:00 |
| Dai'an Holistics - Reflexology & Reiki | Reflexologist | Claytongate Dr | Mon 09:00–17:00 |
| Daisy Luxe Ltd | Handbags shop | Reedfield Pl | Daily Open 24 hours |
| Damian Lee Building Ltd | Builder | 10, 80 Lytham Rd | Mon–Fri 07:30–17:00 |
| Dance Like a Mother - Penwortham | Physical fitness programme | Queensway | Thu 10:00–11:00 |
| Daniel O'Neill Cabinet Maker and Woodcarver | Cabinet maker | 16 Crosby Pl | Mon–Sat 08:00–18:30 |
| Dash Dynamics | Digital printing service | Unit B, Wyresdale, Green Ln W | Mon–Fri 08:00–16:00 |
| Decca Plastics | Plastic fabrication company | Lincoln St | Mon–Thu 08:00–17:00 |
| Deepdale Dental Centre | Dentist | Smart Dental Care, 73c St Gregory Rd | Mon 09:00–18:00 |
| Designer Radiators Direct | Radiator shop | House 6, Rhodes, 18 Tulketh Brow | Mon–Thu 09:00–17:00 |
| Devil Gaming LTD. | Amusement machine supplier | Millennium Rd | Daily Open 24 hours |
| DFJ Automotive Ltd | Alternator supplier | Unit 55 Roman Way | Fri 08:00–17:00 |
| Diamond Dental Care | Dentist | 59-61 Pope Ln | Mon–Thu 08:30–13:00, 14:00–16:30 |
| Digitec Aerials Preston | Antenna service | 9 – 15 Ribbleton Ln | Mon–Fri 08:30–19:30 |
| Disability Equality (nw) Ltd | Disability services and support organization | Disability Equality (NW) Ltd., Community Hub, 23 Sedgwick St | Mon–Fri 09:30–16:00 |
| Dobson Marine Services Ltd | Boat maintenance | 3, Rear of Stonecroft, Woodfold Ln | Mon 08:30–18:00 |
| Door Repairs Preston | Garage door supplier | Blackpool Rd | Sat 09:00–23:30 |
| Dr Hennessy Cosmetic Clinic | Esthetics service | 5A, Millennium Office Park | Mon 09:00–17:00 |
| Dr.Fareeha Health and Wellness Centre | Dermatologist | Unit 1B. First Floor, Fairway office park, Pittman Way | Thu 09:30–18:00 |
| Dreamcatcher Bridal & Prom | Bridal shop | 69 Station Rd | Mon 10:00–17:00 |
| DSR North West | Auto electrical service | St Chad's Rd | Thu 10:00–18:00 |
| Dunbia Preston | Meat processor | Church Rd | Daily 05:00–18:30 |
| Dynojet UK | Motorbike parts shop | Lower House Barn, Strickens Ln | Fri 09:30–16:00 |
| Eagle Herbs - Wellness Clinic | Alternative medicine practitioner | 8-9 Fox St | Thu 10:00–16:30 |