| Varley Park Halls of Residence | Student halls | Coldean Ln | Daily 09:00–17:00 |
| Varndean College | Sixth form college | Surrenden Rd | Mon–Fri 08:00–17:00 |
| Ventisei Pizzeria Napoletana | Pizza restaurant | 26 Preston St | Wed–Thu 17:00–21:30 |
| Vernon Ward Antiques & Jewellery Valuations & Auctions | Auction house | Denehurst, Sunnydale Avenue | Mon–Sat 09:00–17:00 |
| Verti-Grow Ltd | Landscaper | Unit B2, 3 Moulsecoomb Way | Mon–Fri 09:00–17:00 |
| Waterproof Systems Ltd | Water damage restoration service | 63 Ladies' Mile Rd | Mon–Fri 08:30–17:00 |
| We Love Falafel | Falafel restaurant | 37 Sydney St | Mon–Sat 11:00–17:30 |
| We Smile.Club | Teeth whitening service | 21 Regency Square, Preston St | Daily 08:00–20:00 |
| Wedding Rings Direct | Jeweller | 32 Ship St | Thu 10:00–17:30 |
| Wendy's Walk & Board | Dog day care centre | 87 Balsdean Rd | Mon–Wed 08:00–18:00 |
| Whitehawk FC | Football club | McLaren Enclosed Ground, East Park, Wilson Ave | Mon–Sat 08:30–12:30 |
| WiDEYE | Health and beauty shop | 15 Gardner St | Thu 10:30–17:30 |
| Wild Flora Bridal - Wedding Dress Shop Brighton, East Sussex | Bridal shop | 5-6, Circus Parade, New England Rd | Mon–Sat 09:00–16:00 |
| William Stewart Investigations Ltd | Private investigator | Brighton Media Centre, 15-17 Middle St | Daily Open 24 hours |
| Williamson Pumps Ltd | Water pump supplier | Unit 2, Centenary Industrial Estate, Hughes Rd | Mon–Fri 09:00–17:00 |
| Wimpy Portslade | Family restaurant | 14 Station Rd | Mon–Thu 09:00–21:00 |
| Woodbourne Car Sales | Used car dealer | Woodbourne Ave | Mon–Fri 09:00–17:30 |
| Wooden Flooring Centre Ltd | Wood and laminate flooring supplier | 99 Trafalgar Rd | Thu 09:00–16:30 |
| Woodingdean In Business | New service | 1, 58 Warren Rd | Mon–Fri 09:00–17:00 |
| Woodingdean Methodist Church | Methodist church | The Ridgway | Mon 13:00–16:30 |
| Wright Auto Locksmith Brighton & Sussex | Emergency locksmith service | 27 Bodiam Ave | Daily Open 24 hours |
| WS & Sons Roofing Contractors | Roofing service | 4 St Michael's Pl | Daily Open 24 hours |
| YAC Youth Advice Centre | Youth organisation | Jubilee Library, Jubilee St | Mon–Wed 10:00–12:00, 13:00–17:00 |
| Yashar Bish | Oriental rug shop | 96 Gloucester Rd | Mon–Sat 10:00–17:00 |
| YouMeSushi | Sushi takeaway | 169 North St | Daily 11:00–23:00 |
| Youraccompanist | Music publisher | 7 Zion Gardens | Daily Open 24 hours |
| Zaati Indian Arabic restaurant | Kerala restaurant | 29 Preston St | Sun 12:00–23:00 |
| مطعم مندي اليمن Yemen Mandi Restaurant | Middle Eastern restaurant | 79 London Rd | Thu 12:00–23:00 |
| 360 Hair Clinic | Hair replacement service | 63 Queen Victoria Ave | Mon–Tue 09:30–20:00 |
| Amplify Hearing | Audiologist | 47/48 North St | Mon–Thu 09:00–17:30 |