| CDG Farm Services | Agricultural service | Four Acres | Daily Open 24 hours |
| Central Co-op Food - Mosborough | Supermarket | 53 High St | Mon–Sat 07:00–22:00 |
| Central Travel Sheffield Ltd | Coach and minibus hire | The Old Fire Station, Darnall Rd | Daily Open 24 hours |
| Cha Ting 茶亭 | Asian restaurant | 124 Devonshire St | Mon 12:00–22:00 |
| Cheffield South Indian Hut | South Indian restaurant | 831A Barnsley Rd | Fri–Sun 12:00–17:00 |
| China China | Chinese takeaway | 148 Laughton Rd | Mon 17:00–22:00 |
| Chocolate Bar by Bullion | All Day Cafe Bar | Chocolate cafe | 20 22 Cambridge St | Mon–Thu 09:00–21:00 |
| Chop Shop Bar & Grill | Steak house | 1B Alma St | Wed–Thu 17:00–22:00 |
| Christ Church Fulwood | Christian church | Canterbury Ave | Mon–Fri 09:00–17:00 |
| Church on the Corner (Elim) | Pentecostal church | 1-5 Buchanan Rd | Tue 09:00–11:00 |
| City Limits Venue | Function room facility | 607-613 Penistone Rd | Daily Open 24 hours |
| City of Refuge Foursquare Church | Foursquare church | 217 Handsworth Rd | Sun 10:00–13:00 |
| Colour Guru Jen - Seasonal Colour Analysis | Image consultant | 33 Vainor Rd | Mon 09:00–15:00 |
| Cooper's Car Spares | Car breaker | Livesey St | Mon–Fri 08:30–16:00 |
| Cooplands | Bakery | Unit 2, 146 Langsett Rd S | Mon–Sat 07:30–16:00 |
| Cowboy Boot Store | Tienda de botas | 97 Division St | Mon–Fri 11:00–18:00 |
| CrossFit Sheffield | Physical fitness programme | H19 Prospect rd | Mon–Fri 06:30–20:30 |
| Cullen Metcalfe & Co Ltd | Marine supply shop | 21 Totley Hall Croft | Daily Open 24 hours |
| Cutlery Works | Food court | 73 – 101 Neepsend Ln | Mon–Thu 09:00–21:00 |
| Dahlak Restaurant & Bar | Ethiopian restaurant | 9-11 Castle St | Daily 11:00–23:00 |
| Daley Care Centre in Sheffield | Rehabilitation centre | 2A Haywood Ln | Daily Open 24 hours |
| Dave's Hot Chicken | Chicken restaurant | 8, 10 Cambridge St | Mon–Thu 11:00–23:00 |
| Dermaglow Clinic Sheffield | Skin care clinic | First Floor, Blenheim Reach, 861 Ecclesall Rd | Tue–Wed 09:30–17:00 |
| Dickenson Tiling | Tile contractor | 87 May Tree Cl | Daily 08:00–20:00 |
| Dinnington Pharmacy | Pharmacy | New St | Mon–Sat 09:00–21:00 |
| Direct Kitchens | Kitchen renovator | 184 Church St | Mon 09:00–17:00 |
| Diverso Surface Design | Plasterer | 165 Handsworth Rd | Mon–Fri Open 24 hours |
| Dog & Partridge | Irish pub | 56 Trippet Ln | Mon 16:00–23:00 |
| Eco Happy | Boiler supplier | C House, C F, Unit 9 Woodseats Cl | Daily Open 24 hours |
| EEJ Concrete Mix | Ready-mix concrete supplier | Manor Rd | Mon–Fri 07:00–17:30 |