| Northants Venue Hire | Amusement centre | Northants Venue Hire, Gladstone Rd | Mon–Thu 09:00–18:00 |
| Nuts For Your Coffee | Mobile caterer | Heyford Rd | Daily Open 24 hours |
| Oblique | Modern European restaurant | 254 Wellingborough Rd | Tue–Thu 10:00–15:00, 18:00–22:00 |
| OnTarget Range Ltd | Shooting range | 13 Osyth Cl | Tue 10:00–18:00 |
| Opium Restaurant | Asian fusion restaurant | 245-247 Wellingborough Rd | Mon–Sat 12:00–23:00 |
| Oval Service Station | Motorway services | Junction 16, M1- A45 Roundabout | Daily Open 24 hours |
| Palace Restaurant & Bar | West African restaurant | 163 Kettering Rd | Tue–Sun 17:00–02:00 |
| PBF Drainage Services Ltd | Contractor | 15 Rothersthorpe Ave | Daily 08:00–17:00 |
| Plastic Tree Studios | Recording studio | Abington Ave | Sun 10:00–18:00 |
| Pond Farm Close - Anchor | Housing association | Pond, Farm Cl | Mon Open 24 hours |
| Precision Gas & Plumbing Ltd | Plumber | 158 High St | Daily Open 24 hours |
| Professional Handyman Services | Handyman/Handywoman/Handyperson | Knights Ct | Daily Open 24 hours |
| Profield Care | Nursing agency | SUITE 21, NEWTON HOUSE, Kings Park Rd | Daily Open 24 hours |
| Public Gardens | Park and garden | Church St | Daily 07:00–20:00 |
| Purely Orthodontics | Orthodontist | Welford Rd | Daily 09:00–17:00 |
| Real Beauty is parmanetly Closed down | Plastic surgeon | 27 Gibbsacre Ct | Daily Open 24 hours |
| Red Lion Truck Stop | Motorway services | A45 Weedon Rd | Mon–Fri 06:00–23:00 |
| Riverside Hub | Children's amusement centre | Riverside Retail Park, 7 Carousel Way | Mon–Thu 10:00–18:30 |
| Salon Services | Beauty supply store | No 5, Orbital Trade Park, Gladstone Rd | Mon–Fri 08:30–17:30 |
| Scrap Local - Scrap Car Northampton | Scrap yard | Industrial Estate, 1 Ferro Fields | Daily 08:00–22:00 |
| Scrap My Car Northants | Car breaker | Bern Links | Daily 08:30–21:00 |
| SHEvolution Fitness | Pilates studio | 6 Gladiator Cl | Mon 09:00–15:00 |
| Silk and satin Weddings | Limousine service | Lady Winefride's Walk | Mon–Fri 08:00–20:00 |
| Silverstone Leasing - Car Leasing in Northampton | Leasing service | Office 5 - The Old Hay Barn, Preston Lodge Court, Preston Deanery | Mon–Fri 07:00–18:00 |
| Sixfields | Restaurant | Sixfields Leisure | Mon–Thu 09:00–22:30 |
| Smurfit Westrock Northampton | Packaging company | Moulton Way | Mon–Fri Open 24 hours |
| Softwater Solutions Ltd | Water softening equipment supplier | 7 Ash Cl | Mon–Fri 08:00–20:00 |
| Soo Yoga fitness and wellbeing family centre | Wellness centre | Sol Central, Mare Fair | Mon–Fri 09:00–20:00 |
| St Crispin Social Club | Bar | Berrywood Rd | Mon–Tue 19:00–23:00 |
| St Michael & All Angels Church of England | Church | Church Ln | Mon 09:30–16:00 |