| Dynamic Mobile Valeting Services | Valeting service | Station Rd | Daily 09:00–17:00 |
| East Midlands Sub Aqua Club | SCUBA instructor | c/o The Royal Oak, 55 Green Ln | Tue 18:00–21:30 |
| Eastledge Ltd | Dry wall contractor | La, Curzon Ln | Mon–Thu 08:00–16:30 |
| Ebikes Center Derby | Electric bicycle store | 58 Osmaston Rd | Fri 10:30–19:00 |
| EBM Civils limited | Civil engineering company | Hilton Industrial Estate | Mon–Tue Open 24 hours |
| Eden Tyres & Servicing | Tyre shop | Alfreton Rd | Mon–Fri 08:30–17:30 |
| Eighty Seven | Ladies' clothes shop | 5 Market Pl | Tue–Thu 10:00–16:30 |
| Electrician Courses Derby | Electrician | Oberoi Business Hub, 19 St Christopher's Way | Daily Open 24 hours |
| Elite Spray Tech Ltd | Spray Painting & Respraying Services | Painter and decorator | Workshop 1, 92 - 124 Wiltshire Rd | Mon–Tue 08:30–17:30 |
| Elvaston Castle | Park and garden | Borrowash Road | Daily 09:00–17:00 |
| Emily's Steakhouse | British restaurant | 24-26 Monk St | Tue–Thu 18:00–21:00 |
| Emma May SPMU | Permanent make-up clinic | 55 Queen St | Tue–Sat 10:00–18:00 |
| English Wine Project – Winery at Darley Abbey | Winery | Darley Abbey Mills | Thu 09:00–17:00 |
| ETB Tyres & MOT - Derby | Tyre shop | 116 Siddals Rd | Mon–Fri 08:00–17:30 |
| Etwall Leisure Centre | Leisure centre | Hilton Rd | Mon–Tue 06:00–22:00 |
| Etwall Library | Library | Main St | Mon 14:00–17:00 |
| Evans Halshaw Leasing | Car rental service | Pendragon House, Sir Frank Whittle Rd | Mon–Fri 09:00–18:00 |
| Event Inns Ltd. | Party equipment rental service | Sharrow Hall Farm, Cropper Ln | Mon–Sat 09:00–17:00 |
| Evergreen Floors | Wood and laminate flooring supplier | Unit 2, Bemrose Park, Wayzgoose Dr | Mon–Fri 08:00–17:00 |
| Exertion Fitness | Fitness centre | Units 1 and 2, Mickleover Retail Centre, Uttoxeter Rd | Mon 06:00–20:15 |
| Extremeties | Foot care | 8 Portico Rd | Mon 10:00–17:00 |
| Eyetek Surveillance | Security system supplier | Unit 3, 229 Derby Rd | Mon–Fri 09:00–17:00 |
| Facial Perfection - Dr Led Aesthetics Clinic in Derby for Lip filler, Botox & Cosmetic treatments | Cosmetic surgeon | Facial Perfection, 79 Rykneld Rd | Mon–Tue 09:00–19:00 |
| Fairfax Meadow Europe Ltd | Meat wholesaler | Industrial Estate, 6 Newmarket Dr, Osmaston | Mon–Sat 08:00–18:00 |
| Farmhouse at Mackworth | Pizza restaurant | Ashbourne Rd | Mon–Fri 07:00–23:00 |
| Feet Etc | Chiropodist | 34 Main St | Mon–Thu 08:30–16:30 |
| Findern Post Office | Post office | 4 The Green | Mon–Fri 09:00–17:30 |
| First Safety Ltd | Safety equipment supplier | Unit 4, Parker Centre, Mansfield Rd. | Mon–Fri 09:00–17:00 |
| Fletchers Timber Ltd | Timber merchant | 28 Station Rd | Mon–Sat 08:30–17:00 |
| Fletchers Wholesale | Hairdresser | 47 Albert Rd | Tue–Wed Open 24 hours |