| Clock Warehouse | Pub | Shardlow, Derby DE72 2GL | Daily 11:00–23:00 |
| Cocco Salon | Hairdresser | 1 Peel St | Tue–Wed 10:00–20:00 |
| Codfather pizza and fish bar | Fast food restaurant | 99 Holbrook Rd | Mon–Thu 15:00–22:00 |
| Collaborate Events | Event planning service | 1 Etwall Rd | Daily Open 24 hours |
| Commercial Finance Arena | Financial planner | 12, Millennium Way | Mon–Fri 09:00–17:00 |
| Communicate Better English | English language school | 15-19 Ashbourne Rd | Wed–Fri 09:00–17:00 |
| Compamigos: Eat Drink Share | Tapas restaurant | Mercia Marina, Compamigos, Findern Ln | Mon–Thu 10:00–21:00 |
| Complete Canine - Hydrotherapy and Physiotherapy | Rehabilitation centre | Park View | Mon 10:30–21:00 |
| Complete Car Cosmetics | Car body shop | Ascot Business Park, Longbridge Lane | Mon–Fri 08:00–16:30 |
| Computer Rescue Derby | Computer repair service | 10 Queensbury Park Dr | Mon–Fri 09:00–20:00 |
| Copy That! Midlands Ltd. Freelance Copywriter | Marketing agency | Gordon Rd | Mon–Fri 09:00–17:00 |
| Corn Exchange Sports Bar | Sports bar | Corn Exchange, Albert St | Daily 12:00–00:00 |
| Cromwell Tools (Derby) | Tool shop | Business Park, 500 City Gate | Thu 08:00–16:30 |
| Cubit Computers | Computer repair service | 269 Osmaston Rd | Mon–Fri 10:00–17:30 |
| Cueball Derby | Snooker and pool club | Mansfield Rd. | Daily 12:00–23:00 |
| Cyclo Monster Bike Shop | Sports nutrition shop | 76 Derby Rd | Mon–Fri 09:30–17:30 |
| Cygnet Hospital Derby | Psychiatric hospital | 100 London Rd | Daily Open 24 hours |
| D C Fencing & Garden Services | Gardener | 16 Corbel Cl | Mon–Fri 08:00–19:00 |
| Dairy Machinery UK Used Food and Beverage Processing And Packaging Equipment | Food machinery supplier | Unit 8b, Shaftesbury St | Mon–Fri 08:00–17:00 |
| Damsons Coffee House | Cafe | 2 Rectory Ln | Tue–Thu 08:30–16:00 |
| Dan Jones Decorating | Painter and decorator | 13 Bickley Moss | Mon–Sat 07:30–18:00 |
| Dance Cubana | Dance school | The base bar, 19 Jubilee Pkwy | Daily Open 24 hours |
| Dandelion Stationery | Publisher | Industrial Estate, Unit C Barrow Ln, Sinfin Ln | Mon–Thu 08:30–16:30 |
| Daniel Bullock Photography | Photography service | 2b East Ave | Mon–Sat 09:00–17:00 |
| Darley Abbey Wines | Wine bar | The Stables, Darley Abbey Mills | Thu 17:00–23:00 |
| Darley Deli & Co | Deli | The Polishing Shed | Tue–Sat 09:00–17:00 |
| Darren Bywater Dental Implant Centre Derby | Dental implants periodontist | 2 Main Ave | Mon 09:00–17:30 |
| David Ray Commercials Ltd | Truck dealer | Ford Farm, Ford Ln | Thu 08:00–17:30 |
| Day Night Pharmacy and Ear Wax Clinic | Pharmacy | 692-694 Osmaston Rd | Mon–Fri 08:00–22:00 |
| DB Joinery and Building Services Limited | Joiner | 18 Ladybank Rd | Mon–Tue 08:00–17:00 |