| Career Counselor | Career guidance service | 64 Egerton St | Daily Open 24 hours |
| Carme Home Ltd. | Internet shop | Ste 13A, Eagley House, Blackburn Rd | Daily Open 24 hours |
| Carpet & Bed Warehouse Horwich Bolton | Carpet retail shop | 36 Winter Hey Ln | Mon 10:00–16:00 |
| Carrycall, Mobility Hire and Rentals | Wheelchair rental service | 1B, off Gladstone Pl | Mon–Fri 10:00–14:30 |
| Carters Jewellers | Jeweller | Unit, Knowsley St | Fri 09:30–17:00 |
| Castle Hill Youth Club | Youth club | Frogley St | Mon–Fri 08:00–21:00 |
| CDC Outpatient Department | Hospital department | J, CDC, Block, Minerva Rd | Mon–Fri 07:30–20:15 |
| Central Carpets & Furniture | Flooring contractor | Derby St | Mon–Sat 09:00–18:00 |
| Chadwick Health & Protection Limited | Health insurance agency | 7 Conningsby Cl | Mon–Fri 08:00–18:00 |
| Chapelhouse MG Bolton | Car dealer | 204 Bury Rd | Mon–Fri 09:00–18:00 |
| Chapz Barber Shop | Barber shop | 3AG, 33 Market St | Mon–Wed 09:00–17:30 |
| Cherry Blossom BJJ & Wellness | Jiu jitsu school | Unit 50, Flexspace, Manchester Rd | Mon 17:30–20:00 |
| Cheshire Gun Room | Gun shop | 486 Halliwell Rd | Mon–Fri 10:00–17:30 |
| CHILL @ the cowshed | Ice cream shop | 46 Winter Hey Ln | Mon–Sat 09:00–16:00 |
| Chinese Chef | Chinese restaurant | 331 Bury Rd | Mon 11:45–23:00 |
| Chorley Electrical Traders Ltd | Electrical products wholesaler | 107 Halliwell Rd | Mon–Fri 08:00–17:00 |
| Chorley Group Bolton Nissan | Nissan dealer | Higher Bridge St | Mon–Fri 08:30–18:00 |
| Ciao Bella Italiano | Italian restaurant | unit1, 80 George St | Mon–Sat 14:00–23:00 |
| Ciceley Commercials Ltd | Mercedes-benz dealer | Weston St | Mon–Fri 08:00–18:00 |
| Clairabow | Invitation printing service | 243 Leigh Rd | Mon–Fri 10:00–16:00 |
| Clean My Waste Ltd | House clearance service | 34 Hazelwood Rd | Mon–Sat 06:30–18:30 |
| Cleartech Communications Ltd | Internet service provider | Clarence House, 80 Clarence St | Mon–Fri 09:00–17:00 |
| Clever IT | Computer service | Hampson St | Mon–Fri 08:30–17:30 |
| CMG Heating & Plumbing | Gas engineer | 39 Wisbeck Rd | Mon–Fri 08:00–17:00 |
| Cobblers horwich | Shoe repair shop | 61 Winter Hey Ln | Mon 09:00–17:00 |
| Commercial Air Conditioning | Air conditioning store | Unit 1, Station House Farm, 673 Chorley Rd | Mon–Fri 08:00–18:00 |
| Comparo energy | Electric utility company | 120 Bark St | Mon–Fri 08:00–18:00 |
| Compass Fostering | Childcare agency | Larkhill House, 160 St George's Rd | Mon–Fri 09:00–17:00 |
| Complete Koi & Aquatics | Aquarium shop | Unit 4 Tonge Bridge Way | Mon–Sat 09:00–17:00 |
| Computer Care Consultants Ltd | Computer consultant | 112 - 116 Chorley New Rd | Mon–Fri 08:00–17:30 |