| Spa Naturel Sheffield | Spa and health club | 119 Norfolk St | Mon–Thu 06:30–22:00 |
| Speedwell Office Systems | Printing equipment supplier | 15 Paternoster Row | Mon–Fri 08:30–18:00 |
| SpudBros Express | Fast food restaurant | 14 Fargate | Daily 11:00–20:00 |
| St George's Church | Public university | St George's Terrace | Mon–Fri 08:00–18:00 |
| Steel City Shirts - Screen printing/ Custom T-shirt & merchandise printing | Graphic designer | Pond Hill | Mon–Thu 09:30–17:30 |
| SunStratos | Aerospace company | Room 3, George Porter Building, Broad Ln | Daily 09:00–17:00 |
| Surface Savvy Ltd | Repair service | 2 Church St | Thu 09:00–17:00 |
| Tank | Nightclub | 53-55 Arundel Gate | Fri 23:00–05:00 |
| Taylor Bracewell Solicitors | Divorce lawyer | 52 Bank St | Mon–Fri 08:45–17:00 |
| Taylor Emmet Solicitors (Sheffield) | Personal injury lawyer | Isaacs Building, 4 Charles St | Mon–Fri 09:00–17:00 |
| Terra Forum | Information services | Sheffield Science Park Cooper Buildings, technology park, Arundel St | Mon–Fri 09:00–17:00 |
| The Cabin | Brunch restaurant | 10-12 Fitzwilliam St | Mon 09:00–16:00 |
| The Cream Store - Sheffield | Fashion accessories shop | 1 Charles St | Thu 09:30–18:00 |
| The Garage Door Company | Garage door supplier | 125 Matilda St | Mon–Fri 09:00–17:00 |
| The Great Escape Game Sheffield | Escape room centre | St. James House, Vicar Ln | Fri 09:00–23:00 |
| The Moor Market Sheffield | Market | 77 The Moor | Mon–Sat 08:30–17:30 |
| The School Bus | Business-to-business service | Isaacs Building, 4 Charles St | Mon–Fri 09:00–17:00 |
| The Sheffield School of Health & Beauty | Beauty therapy college | Orchard House, Leopold St | Mon–Thu 09:00–21:00 |
| The Smile Designers | Cosmetic dentist | 92a Arundel St | Mon–Fri 08:00–18:00 |
| The Street Food Chef | Mexican restaurant | 90 Arundel St | Mon–Fri 11:00–22:00 |
| Tracey's Quality Fruit & Veg | Greengrocer | Moor Market, 77 The Moor | Mon–Sat 09:00–16:30 |
| Tsuki | Authentic Japanese restaurant | 58-60 West St | Thu 12:00–23:00 |
| Tucum Capoeira Sheffield | Capoeira school | 60 Norfolk St | Tue 18:30–20:30 |
| Twisted Deli | Sandwich shop | 178 Shoreham St | Thu 12:00–16:00 |
| Union St | Co-working space | 18-20 Union St | Mon–Fri 08:30–18:30 |
| Velocity Village | Apartment building | Solly St | Daily Open 24 hours |
| VM Consulting | Occupational safety and health | 7 Castle St | Mon 09:00–17:00 |
| Wanlin Dance School | Dance school | Surrey St | Mon–Fri 10:00–21:00 |
| Westfield Health | Health insurance agency | Westfield House, 60 Charter Row | Mon–Fri 08:30–17:30 |
| White Wedding Videos | Professional Wedding Videographer Sheffield and Yorkshire | Wedding photographer | 14b High St | Daily 07:00–22:00 |