| Raven Silverware co ltd | Silversmith | 90 Matilda St | Mon 09:00–17:00 |
| Robin's Nest Comics | Comic book shop | 43 Hereford St | Fri–Sat 10:00–18:00 |
| Samurai Digital Security LTD | IT security service | Meadowhall Centre, Acero, 1 Concourse Way | Mon 09:00–18:00 |
| Shaolin Fists International | Kung fu school | 94 Surrey St | Fri 18:00–21:00 |
| Sharma Group Of Businesses Ltd | Career guidance service | SPACES ACERO, 1 Concourse Way | Thu 09:00–17:00 |
| Sheffield Assessment Centre | Disability services and support organization | Assessment Centre Spaces, Yorlinc, 1 Concourse Way | Mon–Fri 08:30–17:00 |
| Sheffield Carers Service | Support group | The Workstation, Paternoster Row | Mon–Fri 09:00–17:00 |
| Sheffield Cavendish Court Jobcentre | Government office | 9 Bank St | Mon 09:00–17:00 |
| Sheffield City NHS Walk-In Centre | Walk-in clinic | Sheffield City GP Health Centre, 75 Broad Ln | Daily 08:00–22:00 |
| Sheffield Coach Station | Bus depot | Pond Hill | Thu Open 24 hours |
| Sheffield Credit Union | Credit union | 35 Townhead St | Thu 10:00–14:00 |
| Sheffield Energy Hub | Energy advisory service | 35 Cambridge St | Fri 10:00–16:00 |
| Sheffield Hallam University | University | Howard St | Daily 07:00–21:00 |
| Sheffield Station Cycle Hub | Parking area for bicycles | Cross Turner St | Sat Open 24 hours |
| Sheffield Walking Tours Meet | Tour operator | Outside The Crucible Theatre, 55 Norfolk St | Mon–Sat 10:30–16:00 |
| Sknbyfay | Facial spa | 52 Bank St | Sat 13:00–19:00 |
| Smokey Sams | Tobacco shop | Unit 40, The Moor Market, 77 The Moor | Thu 08:30–17:30 |
| Sorby Centre for Electron Microscopy | Research institute | North Campus, Kroto Research Institute, Broad Lane | Thu–Fri 09:00–17:00 |
| Splatter Central | Art studio | 6 Exchange St | Thu 14:00–20:00 |
| St Johns Buildings | Barrister | 7 Leopold St | Mon–Fri 09:00–18:00 |
| Studio13 Meisner Actor Training | Drama school | Castle St | Sat 11:30–14:30 |
| Swindell & Pearson Ltd | Patent lawyer | Spaces Acero, 1 Concourse Way | Mon 09:00–17:00 |
| Taylor Moss Clinic | Addiction rehabilitation centre | 32 Eyre St | Daily Open 24 hours |
| The Circle | Conference centre | 33 Rockingham Ln | Mon 09:00–16:00 |
| The Common Room | Sports bar | 1st floor, 127 Devonshire St | Thu 15:00–00:00 |
| The Occasionall Group | Festivall Staff & Occasionall Staff | Event management company | The Circle, 33 Rockingham Ln | Mon 12:00–18:00 |
| The Sheffield Music Store | Music shop | First Floor, 14-16 Matilda St | Mon–Sat 09:00–17:30 |
| Translink Corporate Finance UK - Sheffield Office | Investment banking | Albert Works, Sidney St | Fri 09:00–17:00 |
| Tutorful | Private tutor | 5 Block 2, Spaces, 1 Tenter Street Pennine | Mon–Fri 09:00–17:00 |
| Uncle Lins Restaurant Chinese Halal Cuisine | Wok restaurant | 17 Westfield Terrace | Thu 15:00–23:00 |