| Powerflow Exhausts Brighton | Exhaust silencer shop | 1, Grove Garage, 77 Beaconsfield Rd | Mon–Fri 08:30–18:30 |
| Puddle Ducks at Brighton Hilton Metropole | Baby swimming school | Kings Rd | Daily Open 24 hours |
| Quirky Campers - Campervan Hire | Campervan and caravan rental agency | 45 Queen's Park Terrace | Mon–Fri 09:00–17:00 |
| Rawlab | Comic cafe | 73 Trafalgar St | Mon 12:00–18:00 |
| Revolution Revolution Brighton | Lounge bar | 77 West St | Mon–Thu 16:00–01:00 |
| Richer Sounds, Brighton | Audio-visual equipment supplier | 54 London Rd | Mon–Fri 11:00–17:00 |
| RK Bass Records | Record shop | 104 Trafalgar St | Mon 12:00–18:00 |
| Runners Need Brighton | Running shop | 186 Western Rd | Thu 09:00–18:00 |
| Sally Beauty | Barber supply shop | 140A Western Rd | Thu 09:00–18:00 |
| Savers | Discount shop | 6 London Rd | Thu 09:00–19:00 |
| SEA LIFE Brighton | Aquarium | Marine Parade | Mon–Fri 10:00–16:00 |
| Selling My Business - Brighton | Business broker | 26 Stroudley Rd | Mon–Fri 09:00–17:15 |
| sk:n Brighton Jubilee Street | Laser hair removal service | Unit 8, 9 Jubilee St | Thu 09:00–20:00 |
| Slater and Gordon Lawyers | Medical lawyer | Mocatta House | Mon–Fri 09:00–17:00 |
| Snappy Snaps | Photo lab | 30 Duke St | Thu 09:00–18:00 |
| Snow + Rock Brighton | Ski shop | 186 Western Rd | Mon–Sat 09:00–18:00 |
| Spaces Trafalgar Place | Office rental agency | Mocatta House, Blackmore Ct | Thu 08:30–17:30 |
| Specsavers Opticians and Audiologists - Brighton | Hearing aid shop | 49 North St | Mon 09:00–18:00 |
| Sports Direct | Sportswear shop | Unit 2, 134-138 North St | Thu 09:00–19:00 |
| Stowe Family Law LLP - Divorce Solicitors Brighton | Family lawyer | Nile House, Nile Street Projects | Mon–Fri 08:30–19:00 |
| Student Roost - Hillfort House | Student accommodation centre | 1B Moulsecoomb Way | Daily Open 24 hours |
| Sunglass Hut | Sunglasses shop | 69, Churchill Square | Mon–Sat 10:00–20:00 |
| Sussex Interpreting Services (SIS) | Translation service | Community Base, 113 Queens Rd | — |
| Tech Centre Brighton - London Road | Electronics repair shop | 32 London Rd | Mon–Fri 10:00–18:00 |
| Tee Tea Bubble Tea | Bubble tea store | 16, Imperial Arcade | Mon 10:30–22:00 |
| Terrence Higgins Trust | Family planning clinic | 61 Ship St | — |
| The Big Bowl | Vietnamese restaurant | 54 Preston St | — |
| The Ivy Asia Brighton | Asian restaurant | 51 Ship St | Thu 11:30–00:00 |
| The Sushi Co - Brighton | Sushi restaurant | 65 Western Rd | Thu 11:00–04:00 |
| The Works | Office supplies shop | 48-50 Western Rd | Thu 09:00–18:00 |