| Daedalus Drylining & Plastering | Dry wall contractor | Stanton Buildings, Unit 1 Stanton Rd, Regents Park Rd | Daily Open 24 hours |
| Daly Brickwork Ltd | Bricklayer | Clifford St | Daily 07:00–19:00 |
| Damira Dental | Dentist | 10 Cannon St | Daily 08:00–20:00 |
| Damira Shirley Dental Practice | Dentist | 10-12 Cannon St | Daily 08:00–20:00 |
| Dhaba | Indian restaurant | 59 Lodge Rd | Mon 16:00–21:00 |
| Diego's Rotisserie - Restaurant in Southampton | Portuguese restaurant | 10 Bedford Pl | Mon 12:00–22:00 |
| Discover Difference Psychology Clinic | Mental health clinic | The Square, St George's Square | Mon–Sat 09:00–17:00 |
| Dukes Recovery ltd | Towing service | 38 Ashdene Rd | Daily Open 24 hours |
| Earl of Bedlam | Bespoke tailor | Stowe | Daily 09:00–18:00 |
| Eastern Nights | Indian restaurant | 56 Thornhill Park Rd | Sun 17:30–23:30 |
| Ecco Wash | Car wash | Antelope Park, Bursledon Rd | Daily 07:00–19:00 |
| Forest Nightingale Skincare | Cosmetics shop | 36 Ferndale Rd | Daily 09:00–20:00 |
| Freedom Boat Club UK - Hythe Marina Village | Boating club | 14 Shamrock Way | Daily 09:00–17:00 |
| Friends of St. James' Park | Park and garden | St James' Park, St James Rd | Daily Open 24 hours |
| Funky Flamingo Southampton - Lounge & Roof Garden | Bar | 3 Winchester St, Bedford Pl | Tue–Fri 16:00–01:00 |
| GA Marine Engineering Ltd | Shipbuilding and repair company | unit V1, Melbourne St | Daily Open 24 hours |
| Gaff Rigger | Seafood restaurant | Mercury Yacht Harbour & Holiday Park, Satchell Ln | Mon–Sat 08:00–23:00 |
| George Henry builders | Bricklayer | 8 Cedar Ave | Daily Open 24 hours |
| GiroClean | Valeting service | ALEXANDRA HSE, 10-11 Queens Ter | Mon 07:00–20:00 |
| Go Oriental | Chinese supermarket | 18 East St | Mon–Sat 11:00–20:00 |
| GOA Indian Takeaway | Indian takeaway | 66 High Rd | Tue–Sun 16:00–23:00 |
| Grameen spice | Indian takeaway | 45 Bridge Rd | Daily 15:00–23:30 |
| Grange Pet Centre | Pet care store | Woodhouse Ln | Mon–Sat 09:00–17:30 |
| Hampshire Holistic Mobile Therapies | Reflexologist | 19 Satchell Ln | Mon 10:00–19:00 |
| Hampshire Saddlery | Saddlery | Bottings Estate, Station Hill | Mon–Sat 09:30–17:30 |
| Hanover Gables - Anchor | Housing association | 9 Westwood Rd | Daily Open 24 hours |
| Happy Hot Tubs | Hot tub shop | Dobbies Garden Centre, Southampton Rd | Mon–Sat 09:00–17:00 |
| Harper’s Steakhouse with Rooms, Lower Swanwick | Steak house | 286 Bridge Rd | Mon–Fri 07:00–23:00 |
| Harwoods Audi Southampton | Audi dealer | 50-78 Bournemouth Rd | Sun 10:00–16:00 |
| Haskins Garden Centre West End | Garden centre | Gaters Mill, Mansbridge Rd | Mon–Sat 09:00–18:00 |