| CLA Fuels | Fuel supplier | CLA Fuels, The Fuel Depot, Crossley House Ind Est, Leyland Rd | Daily Open 24 hours |
| Cojoe Ltd - Animation | Animation studio | 24 Poulton St | Daily Open 24 hours |
| Concept Cleaning Services & Facilities Management Ltd | Cleaning service | 2 Squirrels Chase | Mon–Wed 07:30–20:00 |
| Country Farm Stud Ltd | Equestrian centre | Lancaster Rd | Daily 09:00–17:00 |
| Crafty Diane Pottery Painting , Gift and Art Gallery, Craft Workshops | Arts and crafts shop | Unit 4, Bridgehouse Marina, Nateby Crossing Ln | Wed–Thu 11:00–16:00 |
| Crystal Clear Details | Valeting service | Unit 1, West view farm | Daily 08:00–18:00 |
| Cuerden Valley Park | Park and garden | Berkeley Dr | Daily Open 24 hours |
| Dai'an Holistics - Reflexology & Reiki | Reflexologist | Claytongate Dr | Mon 09:00–17:00 |
| Daisy Luxe Ltd | Handbags shop | Reedfield Pl | Daily Open 24 hours |
| Devil Gaming LTD. | Amusement machine supplier | Millennium Rd | Daily Open 24 hours |
| Dunbia Preston | Meat processor | Church Rd | Daily 05:00–18:30 |
| Easy Oil | Heating oil supplier | Easy Oil, The Fuel Depot, Crossley House Ind Est, Leyland Rd | Daily Open 24 hours |
| EJM Investigations | Private investigator | Cotton Ct, Church St | Daily Open 24 hours |
| Elctric Ltd | Electrician | 23 Whittingham Ln | Daily Open 24 hours |
| Elliot Grounds Maintenance | Lawn care service | 2 Greenbank Ave | Daily 09:00–20:00 |
| Elroi Multi cuisine kitchen | English restaurant | 182A Plungington Rd | Mon–Fri 12:00–21:00 |
| Elswick Cattery | Cattery | Bonds Ln | Daily 08:30–10:00, 16:00–17:30 |
| Elvin's Kirkham | Lebanese restaurant | 83 Poulton St | Mon–Sat 11:30–21:00 |
| Envirosafe Chartered Consultants | Occupational safety and health | Unit 5, Albert Edward House, The Pavilions | Daily Open 24 hours |
| Equine Herbology | Vitamin & supplements shop | The Weind | Sun 08:30–17:00 |
| Essentialise Workplace Wellbeing | Occupational health service | Suite 4, 9-15 Ribbleton Ln | Mon 08:00–20:00 |
| first call locksmiths | Locksmith | 5 | Daily Open 24 hours |
| Flbp UK Trailer Sales | Trailer dealer | Factory Lane Business Park, Penwortham | Mon–Fri 09:00–17:30 |
| Florenzo Furniture | Office furniture shop | Cotton Ct, Church St | Mon–Fri 10:00–19:00 |
| Fullaloves Wines | Wine bar | Old Stables, The, 5 Stanley St | Sun 12:00–23:00 |
| Fulwood Methodist Church | Methodist church | Watling St Rd | Daily 08:00–22:00 |
| GFC | American restaurant | 45 Blackpool Rd | Daily 16:00–23:00 |
| GJB Group | Cleaners | Millennium Rd, Millennium City Park, Business First Centre | Mon–Fri 07:00–18:30 |
| Goosnargh Huts | Portable building manufacturer | Church House Farm, Mill Ln | Daily 09:00–17:00 |
| Granite House - Granite, Quartz, Marble and Porcelain Worktops. | Granite supplier | Granite House, Strand Rd | Mon–Fri 08:00–17:00 |