| Chutima Therapy | Massage spa | 106 Trafalgar St | Mon–Sat 10:00–19:00 |
| Cielo Cakery | Cake shop | Cielo Cakery St Augustines Arts & Events Centre, Stanford Ave | Daily 08:00–16:00 |
| City Cat Shelter | Animal shelter | 14 Ingham Dr | Mon–Sat 11:00–13:30, 17:00–18:30 |
| City Glass Brighton | Glass repair service | 11 Arundel St | Mon–Sat Open 24 hours |
| CityCoast Church | Evangelical church | North St | Mon–Fri 09:00–17:00 |
| Clear The Gutters | Gutter cleaning service | 17 Coleman St | Daily 08:00–23:00 |
| Cloth Control | Fabric shop | 6a Kensington Gardens | Mon–Sat 10:00–18:00 |
| Coastway Vets, Brighton | Veterinary pharmacy | Freshfield Industrial Estate, Stevenson Rd | Daily Open 24 hours |
| College Of Classical Massage | Massage school | 20-26 Round Hill St | Sat–Sun 09:00–21:00 |
| Concorde 2 | Live music venue | 286A Madeira Dr | Mon–Thu 19:00–23:00 |
| Constantinople Restaurant | Turkish restaurant | 51 Norfolk Square | Daily 12:30–22:00 |
| Couplestherapybrighton.co.uk | Marriage counsellor | 160 Church Rd | Mon–Fri 09:00–20:00 |
| Crunch & Co | Sandwich shop | 7 Church St | Mon–Sat 11:00–17:00 |
| Cyan Brighton | Modern British restaurant | The Grand, 97-99 Kings Rd | Mon–Sat 17:00–21:30 |
| D.R. Computer Repairs | Computer service | 14 Anvil Cl | Mon–Fri 08:00–19:00 |
| Dean Wood Care Home - Bupa | Nursing home | Warren Rd | Daily Open 24 hours |
| Demolition Paintball - Brighton | Paintball centre | Centre, Kings Rd | Daily 09:00–17:00 |
| Detroit Club | Pizza restaurant | 111 St James's St | Tue–Thu 17:00–21:30 |
| Ditto Fabrics Ltd | Fabric shop | 21 Kensington Gardens | Mon–Sat 10:00–17:30 |
| Dowse | Homewares shop | 37 Gardner St | Daily 11:00–17:00 |
| DrainBoss Plumbing & Drainage Ltd. | Drainage service | 18 Margaret St | Daily Open 24 hours |
| Driveway Cleaning Sussex | Pressure washing service | 27 St Luke's Rd | Daily Open 24 hours |
| Duck Inn | Gastropub | 89 High St | Mon–Tue 15:00–00:00 |
| East Street Tap | Pub | 74 East St | Mon–Wed 12:00–02:00 |
| Easy Clean Sussex Ltd | Cleaners | 23 Coombe Terrace | Daily 09:00–17:00 |
| eeny meeny kids ltd | Childrens shop | 32-34 High St | Mon 09:30–12:30 |
| Era Brighton | Antique furniture shop | 92 Trafalgar St | Mon 10:30–16:30 |
| Erasmus+ Brighton Ltd | Foreign exchange students organization | 15-17 Middle St | Daily Open 24 hours |
| Escape the Vault - Escape Room | Escape room centre | London Rd | Mon–Sat 10:00–00:00 |
| Evermade | Poster shop | Ste 1, 2nd Floor, Vantage Point, New England Rd | Daily 10:00–18:00 |