| Defy Time Cosmetic Clinic | Plastic surgeon | 466 Gower Rd | Mon 10:00–17:00 |
| Denny's Swansea | American restaurant | Parc Tawe Retail Park | Thu 09:00–20:00 |
| Digital Solutions Wales | Cable provider | 72 Bryn-Y-Mor Road | Mon–Fri 08:00–17:00 |
| Dilly's Kitchen Ltd | Caterer | 3 Dillwyn Rd | Thu 09:00–16:00 |
| Ditch Witch UK & Ireland - Swansea | Equipment supplier | Phoenix Way Garngoch Industrial Estate | Fri 08:00–17:00 |
| DL Motors | Vehicle repair shop | Meadow St | Mon–Fri 09:00–16:30 |
| DNA 'The New Breed' | Kickboxing school | 9 Francis St | Mon–Fri 09:00–20:00 |
| Dolly Rocks Hair and Beauty | Hair extension technician | 20 West St | Tue 09:30–17:00 |
| Dosa Bar | South Indian restaurant | Green Dragon Ln | Mon 17:00–23:00 |
| Down By Here | Live music venue | 210 High St | Wed–Thu 17:00–23:00 |
| DS Executive Travel Services | Chauffeur service | 9 Blackthorn Pl | Mon Open 24 hours |
| DS Store Swansea | DS automobiles dealer | DS Automobiles FRF, Neath Rd | Tue 09:00–18:00 |
| DTR Medical Ltd | Manufacturer | DTR Medical, Swansea Enterprise Park, 17 Clarion Cl | Mon–Fri 08:00–17:00 |
| DWJ Display | Sign shop | Viking Way, Winch Wen Industrial Estate, Unit 2 Ash Court | Mon–Fri 09:00–05:00 |
| DWJ Group | Commercial printer | Winch Wen Industrial Estate, 2, Ash Court, Viking Way | Mon 09:00–17:00 |
| Dylan Thomas Theatre | Theatre company | Gloucester Pl | Mon–Fri 10:00–14:00 |
| Dynamic Rock | Rock climbing gym | Dynamic Rock, 16 - 18 Hebron Rd | Tue 10:00–22:00 |
| Eaton Fencing | Fence supply shop | Gorseinon Rd | Mon 07:30–17:00 |
| Ebenezer Baptist Church | Baptist church | Ebenezer St | Wed 19:20–21:00 |
| Ecola U.K. Lights and fixtures | Lighting shop | R/O, 1021 Carmarthen Rd | Mon–Fri 08:30–19:00 |
| Eddy's Restaurant | Breakfast restaurant | Caravan Park Ltd | Sat–Sun 09:00–15:00 |
| EFT Consult | Consultant | Phoenix House, Enterprise Park, Llys Felin Newydd | Mon–Fri 08:00–17:00 |
| El Pescador Restaurant & Bar | Fish and seafood restaurant | Trawler Rd | Tue–Fri 13:30–23:30 |
| Electechs | Electrical engineer | Swansea Enterprise Park, Unit, B5 Ashmount Business Park | Mon 07:00–15:30 |
| Electronic Services Ltd | Appliance repair service | 1A Europa Way | Mon–Fri 08:00–16:00 |
| Elysium Gallery & Studios | Events venue | 12-24 Bellevue Way | Thu 11:00–17:00 |
| Enterprise Insurance Services Ltd | Insurance agency | Tawe Business Village, Swansea Enterprise Park, 22 Phoenix Way | Mon–Fri 09:00–17:00 |
| Espresso Head Engineering | Coffee machine supplier | 33 High St | Mon 08:00–17:00 |
| Estate Capital Financial Management | Investment service | 7 Uplands Cres | Mon–Fri 08:00–17:00 |
| Et voilà beauty | Waxing hair-removal service | Unit 2, Squire Court, Victoria Quay | Tue 09:00–17:00 |