| Cafe Creme | Coffee store | 9 High St | Mon 08:30–16:30 |
| Cafe Racer Kits Ltd | Motorcycle shop | Tenter St | Mon–Fri 09:00–17:00 |
| Caffe forno | Tea and coffee shop | caffe forno, Spartan house, 20 Carlisle St | Daily 12:00–22:00 |
| Caffe Piazza | Italian restaurant | 18 Church St | Mon–Sat 10:00–20:00 |
| cake palace | Cake shop | 626 Staniforth Rd | Mon–Sat 11:00–20:00 |
| Cambridge Street Collective | Food court | 11 Backfields | Mon 08:00–23:00 |
| Caravan Man | Caravan repair shop | Hallwood Rd | Fri–Sat 07:00–18:00 |
| Carmel of the Holy Spirit | Monastery | Kirk Edge Rd | Daily 08:00–09:00 |
| Carney Academy Sheffield | Drama school | The Montgomery Theatre, 27 Surrey St | Daily Open 24 hours |
| Carrfield Medical Centre | GP | Carrfield St | Mon–Fri 08:00–18:30 |
| Carsave Leasing Ltd | Car finance and loan company | 5, Sheaf Valley House, 134 Archer Rd | Fri 09:00–17:30 |
| Carter Thomas Solicitors | Immigration lawyer | Digital Campus, electric works, 3 Concourse Way | Mon–Fri 09:00–17:00 |
| Carterknowle Junior School | Primary school | Carter Knowle Rd | Mon–Fri 08:50–15:30 |
| CC Motors | Used car dealer | Unit 4 Dannemora Dr | Mon–Fri 09:00–17:00 |
| CDG Farm Services | Agricultural service | Four Acres | Daily Open 24 hours |
| Central Co-op Food - Mosborough | Supermarket | 53 High St | Mon–Sat 07:00–22:00 |
| Central Glass Ltd | Glazier | Unit 2 Well Meadow St | Mon–Fri 07:00–14:30 |
| Central Travel Sheffield Ltd | Coach and minibus hire | The Old Fire Station, Darnall Rd | Daily Open 24 hours |
| Cha Ting 茶亭 | Asian restaurant | 124 Devonshire St | Mon 12:00–22:00 |
| Chapeltown Karate Club | Martial arts club | 4 Burncross Rd | Mon–Tue 18:00–20:00 |
| Chaps IT Recycling LTD | Computer service | Thorncliffe Park Estate, Unit 26 Chambers Way, Newton Chambers Rd | Mon–Fri 09:00–17:00 |
| Chapter II | Public relations firm | Workspace, 2.13 Wizu, 32 Eyre St | Mon–Fri 09:00–17:00 |
| Charnock Hall Primary Academy | Sixth form college | Carter Hall Rd | Mon–Fri 08:30–15:30 |
| Cheffield South Indian Hut | South Indian restaurant | 831A Barnsley Rd | Fri–Sun 12:00–17:00 |
| China China | Chinese takeaway | 148 Laughton Rd | Mon 17:00–22:00 |
| Chocolate Bar by Bullion | All Day Cafe Bar | Chocolate cafe | 20 22 Cambridge St | Mon–Thu 09:00–21:00 |
| Chop Shop Bar & Grill | Steak house | 1B Alma St | Wed–Thu 17:00–22:00 |
| Christ Church Fulwood | Christian church | Canterbury Ave | Mon–Fri 09:00–17:00 |
| Chrysalis Courses | Learning centre | Hallam University, City Campus, Howard St | Mon–Fri 09:00–17:00 |
| Church on the Corner (Elim) | Pentecostal church | 1-5 Buchanan Rd | Tue 09:00–11:00 |