| Angels and Fishes Christening and Occasion wear | Clothes and fabric manufacturer | Anfi Studio (Office Only, 4 Springer Straight | Mon 09:00–17:00 |
| Arcteck Designs | Architectural designer | 90 Billing Rd | Sat 09:30–12:00 |
| Ardot | Occupational therapist | 69 Station Rd | Mon–Fri 09:00–17:00 |
| Auction Marketer | Marketing agency | Unit 35, Vulcan Works, 34-38 Guildhall Rd | Mon–Fri 09:00–17:30 |
| Aurora Clinics | Plastic surgeon | 82 Billing Rd | Mon–Fri 09:00–17:00 |
| Automotive Services Kiingsley | Auto electrical service | 43 Ash St | Mon–Sat 09:00–18:30 |
| AV Hughes Properties | Short term apartment rental agency | 97 St Johns Ave | Daily 09:00–16:30 |
| B-be Clothing | Promotional products supplier | 42 Brashland Dr | Mon–Thu 09:00–17:00 |
| Baloo Northampton | Indian restaurant | 25 St Leonards Rd | Daily 17:00–22:30 |
| Bare Beauty Aesthetics LTD & Bare Ink Co | Permanent make-up clinic | Basement (Rear Entrance, 38 Billing Rd | Wed–Fri 10:00–17:00 |
| Barker Factory Shop | Shoe shop | Station Rd | Mon–Fri 10:00–17:00 |
| Barratts Snooker Club & Bar | Sports bar | Kingsthorpe Rd | Mon–Thu 09:00–23:00 |
| Bay17 Indoor Golf and Social Club | Indoor golf course | The Royal Ordnance Depot, Bridge St | Mon 10:00–22:00 |
| BDE Northampton Ltd | Steel supplier | Industrial Estate, Ross Rd, Weedon Rd | Mon–Fri 08:30–17:00 |
| Beanworks Coffee Roastery | Coffee roastery | Courteenhall Rd | Mon–Fri 09:00–16:30 |
| Beauty from the Inside Out | Medical spa | 20 Beverley Cres | Mon 18:00–20:30 |
| BEB Contract & Legal Services | Legal services | St. Luke's Centre, Main Rd | Mon–Fri 08:30–16:30 |
| Bec Aggregates | Landscaping supply shop | Bridge St | Mon–Thu 07:00–17:00 |
| Bee International | Immigration lawyer | 19 Horse Market | Mon–Sat 09:00–18:00 |
| Bell | Calor Gas | Gas company | Kingsthorpe, Northampton NN2 6LT | Mon–Sat 08:00–17:00 |
| Bella Pizza & kebab | Pizza restaurant | 2a High St | Tue 15:00–23:00 |
| Betty Bees Curtain Workshop | Curtain maker and retailer | 16 Wellingborough Rd | Sat 09:00–15:00 |
| Bikini Wax Shack | Waxing hair-removal service | 84 Larkhall Ln | Daily 08:45–20:15 |
| Billing Finance Ltd | Car finance and loan company | Billing Ho/The Causeway | Mon 08:30–17:30 |
| Bites Blvd | Tea room | 23a Gold St | Mon–Thu 11:00–23:30 |
| Blackwell Structural Consultants Ltd | Structural engineer | Grange Ln | Mon–Fri 09:00–17:00 |
| Bliss Lane Nursery | Nursery | 34 Bliss Ln | Mon 10:00–16:00 |
| Blisworth Hill Offices | Business park | Blisworth Hill Farm, Stoke Rd | Fri 09:00–17:00 |
| Blooming Good Honey | Honey farm | 4 East St | Fri 09:00–17:00 |
| Boating Leisure Services | Boat builders | Heyford Fields, Bugbrooke Rd | Mon–Fri 08:00–17:00 |