| Cromer House Dental Practice | Cosmetic dentist | 20 Archway Rd | Mon–Tue 09:00–17:30 |
| Crosby Chiropractic & Wellness Clinic | Osteopathy, Sports Therapy | Chiropractor | 28 St John's Rd | Tue–Thu 09:00–20:00 |
| Crosby Coffee Hightown | Coffee roastery | 2 Alt Rd | Mon–Tue 08:00–17:00 |
| Crosby Coffee Lark Lane | Coffee roastery | 62 Lark Ln | Mon–Fri 08:00–17:00 |
| Crosby Village Eyewear | Optician | 63 Liverpool Rd | Mon 09:00–17:00 |
| Cu-Plas Liverpool | Construction material wholesaler | 60-68 Durning Rd | Mon 07:30–17:30 |
| Curly Music | Musical instrument shop | 38 Renshaw St | Mon–Sat 10:00–17:00 |
| Curtins | Engineering consultant | 51-55 Tithebarn St | Mon–Fri 08:30–17:00 |
| CW Glass Ltd | Glass shop | 2 Hapsford Rd | Mon–Thu 08:00–16:00 |
| D. Callaghan & Son | Plasterer | 30 Greenloons Walk | Daily 09:00–17:00 |
| Daily Maid Liverpool | Dry cleaner | 336 Longmoor Ln | Mon–Thu 08:30–16:30 |
| Data Recovery Experts | Computer service | 1 Holmwood Cl | Daily 09:00–20:00 |
| davidlongstaffe | Photographer | 387-393 Edge Ln | Tue 10:00–13:00 |
| Deesisions "the promotional gift company" 25 years in business in 2024 | Promotional products supplier | 4 Greenbank Rd | Mon–Fri 09:00–17:00 |
| Delhi House Liverpool | Modern Indian restaurant | Unit 2b, Britannia Pavilion, Royal Albert Docks | Mon–Thu 12:00–21:30 |
| Delifonseca Dockside | Delicatessen | Brunswick Way | Thu 08:00–18:00 |
| Design 4 Life Tattoo and Piercing | Tattoo shop | 70 Lime St | Mon–Thu 10:00–18:00 |
| Detailed Developers | Building consultant | 17 Lord Nelson St | Daily Open 24 hours |
| DIEM Ltd | Environmental consultant | Jubilee Rd | Mon–Fri 09:00–17:00 |
| Dinas Apartments | Short term apartment rental agency | Dinas Ln | Daily 09:00–21:00 |
| Dirty Motors Valeting | Valeting service | 8 St Luke's Way | Daily 09:00–19:00 |
| DISCOUNT BUILDING SUPPLIES Ltd. | Proveedor de materiales de construcción | Knowsley Industrial Estate, Birchill Rd | Mon–Fri 07:00–17:00 |
| Discount Office Furniture Merseyside | Corporate office | Chester Walk | Mon–Tue 09:00–17:30 |
| Ditchburn Truck Services LLP - Isuzu Liverpool | Truck dealer | Unit 37 & Unit 40, Sefton Ln | Mon–Fri 08:00–17:30 |
| DoggyVIP Field & Park and Raw Dog Food Shop | Dog park | Brook Farm, Moss Side | Mon 10:00–16:00 |
| Dogs Trust Merseyside Rehoming Centre | Animal rescue service | Whiston Ln | Mon 12:00–16:00 |
| DoLocal Digital Marketing Agency | Internet marketing service | Inside Clockwise, Edward pavilion | Mon–Fri 09:30–17:00 |
| Down the Hatch | Vegan restaurant | Basement, 62 Duke St | Thu 13:00–21:00 |
| Driver Training Solutions | Driving school | 48 Beech Rd | Sat–Sun 09:00–21:00 |
| Dry Ice Supply UK Limited (Dry Ice UK & Dry Ice Manufacturer) | Dry ice supplier | Venture House, 90 Evans Rd | Daily Open 24 hours |