| Skin Surgery Clinic | Plastic surgeon | Minor Ops Suite, 78 Back Ln | Mon 09:00–17:00 |
| The Happy Little Nest | Pregnancy care centre | 2 Aldersyde Rd | Daily Open 24 hours |
| The Online Cider Shop | Alcoholic beverage wholesaler | The Sidings, Station Rd | Fri 09:00–17:00 |
| The Wharfedale Clinic | Sports injury clinic | Barden House, 50 Park Rd | Mon 09:00–17:15 |
| Threshfield Catering Supplies | Fruit and vegetable wholesaler | 2 Station Rd | Mon 08:00–12:00 |
| Veg Box Co | Grocery delivery service | 3 Station Rd | Mon Open 24 hours |
| Windsor Interiors | Kitchen renovator | 10 Otley Rd | Mon–Sat 09:30–17:30 |
| Yorkshire Sharpening & Supplies Ltd. | Sharpening service | 9 The Oaks | Fri 09:00–16:30 |
| Bensons for Beds Guiseley | Bedroom furniture store | Unit 8, westside retail park | Mon 10:00–18:00 |
| City Electrical Factors Ltd (CEF) | Electrical products wholesaler | Unit 1, The Sidings, Station Rd | Mon–Fri 07:30–17:30 |
| Currys | Electronics retail and repair shop | Unit 7B, westside retail park, Leeds Rd | Mon–Fri 09:00–20:00 |
| eurochange Leeds - Morrisons - Guiseley | Currency exchange service | 89 Otley Rd | Mon 09:00–17:30 |
| GAME | Video game shop | Unit 7A, westside retail park, Leeds Rd | Wed 09:00–20:00 |
| Hobbycraft Guiseley | Craft shop | Unit 2, Guiseley Retail Park, Park Rd | Mon–Tue 09:00–20:00 |
| HSL Guiseley | Home furniture shop | Otley Road, White Cross, Guiseley | Mon–Tue 09:00–17:00 |
| Magnet Trade | Kitchen supply shop | White Cross Garage, Bradford Rd | Mon–Fri 07:30–17:00 |
| Mountain Warehouse | Ladies' clothes shop | Unit 1, Guiseley Retail Park, Park Rd | Mon–Tue 09:00–19:00 |
| Screwfix Guiseley | Tool shop | International House, South View Business Park, Ghyll Royd | Mon–Fri 07:00–20:00 |
| Sports Direct | Sportswear shop | Unit 7A, westside retail park, Leeds Rd | Mon–Fri 09:00–20:00 |
| Timpson | Shoe repair shop | 89 Otley Rd | Fri–Sat 09:00–18:00 |
| Abraham Moon & Sons | Fabric product manufacturer | Netherfield Rd | Mon–Fri 09:00–17:00 |
| Andrew Abbiss Chimney Sweeps | Chimney sweep | 46 Netherfield Rd | Sun Open 24 hours |
| Brewtique | Beer shop | The Sidings, Station Rd | Daily Open 24 hours |
| CATS Limited | Computer consultant | 3, The Courtyard Bldg, Hawksworth Estate, Thorpe Ln | Mon–Fri 08:30–17:00 |
| Dalesman Diecast | Model shop | 38 Victoria Rd | Mon–Sat 09:30–17:00 |
| Eden Repair Centre | Mobile phone repair shop | Sycamore House, Station Rd | Mon 09:00–17:00 |
| EWR SERVICES EAR WAX REMOVAL BY Sarah LTD | Health consultant | 28 Tranfield Ave | Mon Open 24 hours |
| Healthwise Nutrition by Dr Lisa Gatenby | Nutritionist | Healthwise Nutrition Clinic, 31A Back Ln | Mon–Fri 09:00–17:30 |
| Homesense Guiseley | Homewares shop | Unit 4B, westside retail park | Mon–Tue 09:00–20:00 |
| MAS Design Consultants Ltd | Architecture firm | 1 Oxford St | Mon–Fri 09:00–17:00 |